![]() ![]() The nanofibers formed by these molecules were shown to form a 3D network mimicking the structural proteins in the extracellular matrix. Like heparin, this molecule has the ability to interact with growth factors and effectively enhance their bioactivity. We designed and synthesized a self-assembling peptide amphiphile molecule that is functionalized with biologically active groups to mimic heparin. ![]() ![]() Here we report for the first time induction of angiogenesis by a synthetic nanofibrous peptide scaffold without the addition of any exogenous growth factors or heparin. Therefore, exogeneous heparin or growth factors were required for promoting angiogenesis in previous regenerative medicine studies. Glycosaminoglycans (e.g., heparan sulphates) in the extracellular matrix aid in proper functioning of these growth factors. Induction of angiogenesis is usually triggered by growth factors released by cells. New blood vessel formation (angiogenesis) is one of the most important processes required for functional tissue formation. ![]()
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